HIV Vaccine Development

Gizmodo - HIV Vaccine, 90% Success
Spanish researchers have completed the first human trial of a new vaccine against HIV. It has been successful in 90% of the HIV-free volunteers during phase I testing. This vaccine brings great hope to eradicate this plague forever.

(Gizmodo went with "killing it", not totally accurate but good enough)

Blood Pressure Vaccine

CYT006-AngQb, a blood pressure vaccination, is currently being investigated. It acts as a vaccine against angiotensin II. This might be an excellent way to ensure adherence - given that the vaccine is proven to be effective. Of course, the patient would need to tolerate ACE-Is prior to attempting a vaccine.
Wiki - CYT006-AngQb

Cocaine Vaccine

Med Page Today - Cocaine Vaccine
A vaccine against cocaine was effective in nearly 40% of users of the drug, researchers said.